Product Name: TOP1 Antibody#79971
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation:
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 899507-36-9
Product: A 438079
Specificity Sensitivity: TOP1 Antibody recognizes endogenous levels of total TOP1 protein.
Species Reactivity: Human, Mouse, Rat
Source Purification: Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly214 of human TOP1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background: DNA topoisomerases I and II are nuclear enzymes; type II consists of two highly homologous isoforms: topoisomerase IIα and IIβ. These enzymes regulate the topology of DNA, maintain genomic integrity, and are essential for processes such as DNA replication
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/16648630?dopt=Abstract
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