Product Name :
TY-52156
Description:
TY-52156 is a potent and selective S1P3 receptor antagonist with a Ki value of 110 nM.
CAS:
934369-14-9
Molecular Weight:
364.27
Formula:
C18H19Cl2N3O
Chemical Name:
(Z)-N’-(4-chlorophenyl)-N-[(4-chlorophenyl)amino]-3,3-dimethyl-2-oxobutanimidamide
Smiles :
CC(C)(C)C(=O)/C(/NNC1C=CC(Cl)=CC=1)=N/C1C=CC(Cl)=CC=1
InChiKey:
XONRRGIRSGNWFP-UHFFFAOYSA-N
InChi :
InChI=1S/C18H19Cl2N3O/c1-18(2,3)16(24)17(21-14-8-4-12(19)5-9-14)23-22-15-10-6-13(20)7-11-15/h4-11,22H,1-3H3,(H,21,23)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
TY-52156 is a potent and selective S1P3 receptor antagonist with a Ki value of 110 nM.|Product information|CAS Number: 934369-14-9|Molecular Weight: 364.27|Formula: C18H19Cl2N3O|Chemical Name: (Z)-N’-(4-chlorophenyl)-N-[(4-chlorophenyl)amino]-3,3-dimethyl-2-oxobutanimidamide|Smiles: CC(C)(C)C(=O)/C(/NNC1C=CC(Cl)=CC=1)=N/C1C=CC(Cl)=CC=1|InChiKey: XONRRGIRSGNWFP-UHFFFAOYSA-N|InChi: InChI=1S/C18H19Cl2N3O/c1-18(2,3)16(24)17(21-14-8-4-12(19)5-9-14)23-22-15-10-6-13(20)7-11-15/h4-11,22H,1-3H3,(H,21,23)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 100 mg/mL (274.Erdafitinib Data Sheet 52 mM).Nystatin Anti-infection |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32921256 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|TY-52156 inhibits the S1P3 receptor-dependent increase in [Ca2+]i. TY-52156 shows submicromolar potency and a high degree of selectivity for S1P3 receptor. TY-52156 (10 μM; 10 min) inhibits S1P-induced p44/p42 MAPK phosphorylation.|In Vivo:|TY-52156 (10 mg/kg, 30 mg/kg; p.o.) suppresses S1P3 receptor-induced bradycardia after oral administration in vivo.|Products are for research use only. Not for human use.|
