64.98 (13.81) 63.55 (14.70) 63.37 (13.68) -12.50 (18.06) -12.40 (18.91) -6.35 (16.18) -24.37 (21.37) -22.21 (21.66)a -10.98 (22.14)a -24.37 (22.19) -23.19 (23.29)aConcomitant

64.98 (13.81) 63.55 (14.70) 63.37 (13.68) -12.50 (18.06) -12.40 (18.91) -6.35 (16.18) -24.37 (21.37) -22.21 (21.66)a -10.98 (22.14)a -24.37 (22.19) -23.19 (23.29)aConcomitant analgesic allowedd YesOA siteAbou-Raya et al. 2012 [49]b Afilalo et al. 2010 [50]f Study NCT00421928 Baerwald et al. 2010 [51]bDuloxetine Placebo Oxycodone 4000 mg Placebo Naproxen 1000 mg Placebo144 144 342 337 156 331 202 198 203 231 241 127 244 247 117 185 186 432 214 128 128 111 120 318 313 199 199 20268.9 68.5 58.two 58.2 62.26 63.29 63 62 62 62.1 62.5 62.eight 61.9 62.2 60.9 59.7 60.five 62 62 63.16 61.9 62.07 62.48 59.four 58.two 62 59.7 60 58.16 17 59 59 32.1 37.two 72 71 75 66.2 69.7 65.4 69.7 61.9 65 67 73 64 62 70 84 63.06 67.5 66.7 63.9 62.three 61.eight 64.9 68.5.7 five.NoKneeNoNot mentionedKneeYesNoHipBensen et al. 1999 [52]Celecoxib 200 mg Naproxen 1000 mg Placebo9 10NoNoKneeBingham et al. 2007a [53]Etoricoxib 30 mg Celecoxib 200 mg PlaceboYesNoHip/kneeBingham et al.Rofecoxib 2007b [53]Etoricoxib 30 mg Celecoxib 200 mg PlaceboYesNoHip/knee-12.29 (22.63)a -23.46 (24.51)aBoswell et al. 2008 [54] Burch et al. 2007 [55]f Study NCT00833794 Chappell et al. 2011 [26]b Study NCT00433290 Chappell et al. 2009 [27]b Study NCT00408421 Clegg et al. 2006 [56]b, eCelecoxib 200 mg Placebo Tramadol 20000 mg Placebo Duloxetine 6020 mg Placebo Duloxetine 6020 mg Placebo Celecoxib 200 mg Placebo8.8NoNoKnee-18.46 (23.46)a 34.96 (14.74)g 35.20 (15.13)g -20.50 (11.87) -16.25 (12.26) -24.01 (16.07) -16.81 (13.67) -17.95 (14.98) -14.58 (15.99) -16.24 (24.22) -22.ten (24.16) -25.60 (24.58) -17.73 (24.28)YesNoKnee51.63 (ten.45) 53.82 (9.04) 57.ten (12.15) 56.51 (11.12) 47.ten (13.36) 46.23 (13.49) 61.13 (14.02) 60.37 (15.93) 58.21 (15.26) 59.95 (15.49)eight.14 6.74 9.04 9.3 10.1 9.5 8.five 7.6 8 7.NoYesKneeNoYesKneeNoYesKneeDeLemos et al. 2011 [57]Tramadol 200 mg Tramadol 300 mg Celecoxib 200 mg PlaceboNoNoHip/kneePage 4 ofMyers et al. BMC Musculoskeletal Disorders 2014, 15:76 http://www.biomedcentral/1471-2474/15/Table 1 Qualities of all incorporated research (Alphabetically ordered) (Continued)Essex et al. 2012 [58]c Celecoxib 200 mg Naproxen 1000 mg Fishman et al. 2007 [59] Tramadol 200 mg Tramadol 300 mg Placebo Fleischmann et al. 2006 [60]b296 293 107 105 224 444 231 63 66 201 201 205 242 124 244 122 205 205 207 207 218 420 424 224 221 56 56 51 224 21360 60.7 61 60 61 61.3 61.five 62.52 62.45 59.1 58.5 56.4 33.2 32.7 33 33 60.four 60.3 62 64 64 62.9 61.7 62.93 63.16 64.09 62 64 62.1 62.356.15 (15.42) 56.56 (15.73) 58.42 (13.99) 63.74 (15.21) 61.29 (14.16) 50.94 (16.76) 48.65 (16.97)-23.13 (19.71) -23.54 (19.61) -24.39 (21.19)a -25.54 (44.61) -18.82 (38.32) -16.67 (18.95) -9.69 (16.82) 41.60 (20.50)g 50.40 (22.50)g -21.25 (23.92) -20.27 (23.81) -14.19 (23.45) -5.56 (40.51)a, -4.36 (41.89)a,h64.9 67.6 59.eight 65.Levofloxacin 7 61.PMID:23460641 six 67.1 66.two 65.1 59.1 63.7 59.two 68.8 61.2 66.7.2 eight.YesNoKneeNoYesKneeCelecoxib 200 mg Placebo6.7 six.six 7.94 7.76 7.7 eight 7.NoNoKneeFleischmann et al. 2001 [61]bTramadol 20000 mg PlaceboYesNoKneeGana et al. 2006 [36]Tramadol 200 mg Tramadol 300 mg Placebo63.77 (13.14) 60.10 (14.73) 61.82 (14.82)NoNoHip/kneeHochberg et al. 2011a [62]Celcoxib 200 mg PlaceboYesYesKneeHochberg et al. 2011b [62]Celecoxib 200 mg Placeboh62.7 63.KneeKivitz et al. 2002 [63]Naproxen 1000 mg Placebo55.91 55.72 52.29 (16.73) 51.88 (17.24) 52.81 (15.60) 52.60 (14.93) 51.77 (15.09) 63.84 (13.89) 63.76 (13.36) 68.11 (ten.83) 64.70 (15.71)a 63.80 (15.00) 64.95 63.18 64.-18.79 (19.78) -14.04 (19.71) -10.10 (15.92) -11.98 (16.07) -4.38 (15.70) -15.31 (1.