Product Name :
Indirubin-3′-monoxime-5-sulphonic acid
Description:
Indirubin-3′-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively.
CAS:
331467-05-1
Molecular Weight:
357.34
Formula:
C16H11N3O5S
Chemical Name:
(E, 3E)-3-(hydroxyimino)-2′-oxo-1′, 2′-dihydro-1H, 3H-[2, 3′-biindolylidene]-5′-sulfonic acid
Smiles :
O/N=C1/C(/NC2=CC=CC=C/12)=C1/C2=CC(=CC=C2NC/1=O)S(O)(=O)=O
InChiKey:
VUIXUTVIIOVVHV-OIXOFKMYSA-N
InChi :
InChI=1S/C16H11N3O5S/c20-16-13(10-7-8(25(22,23)24)5-6-12(10)18-16)15-14(19-21)9-3-1-2-4-11(9)17-15/h1-7,17,21H,(H,18,20)(H,22,23,24)/b15-13+,19-14+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.{{Denosumab} web|{Denosumab} NF-κB|{Denosumab} Protocol|{Denosumab} Formula|{Denosumab} supplier|{Denosumab} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Indirubin-3′-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively.|Product information|CAS Number: 331467-05-1|Molecular Weight: 357.34|Formula: C16H11N3O5S|Chemical Name: (E, 3E)-3-(hydroxyimino)-2′-oxo-1′, 2′-dihydro-1H, 3H-[2, 3′-biindolylidene]-5′-sulfonic acid|Smiles: O/N=C1/C(/NC2=CC=CC=C/12)=C1/C2=CC(=CC=C2NC/1=O)S(O)(=O)=O|InChiKey: VUIXUTVIIOVVHV-OIXOFKMYSA-N|InChi: InChI=1S/C16H11N3O5S/c20-16-13(10-7-8(25(22,23)24)5-6-12(10)18-16)15-14(19-21)9-3-1-2-4-11(9)17-15/h1-7,17,21H,(H,18,20)(H,22,23,24)/b15-13+,19-14+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Calcifediol} MedChemExpress|{Calcifediol} Endogenous Metabolite|{Calcifediol} Technical Information|{Calcifediol} Description|{Calcifediol} supplier|{Calcifediol} Autophagy} |Shelf Life: ≥360 days if stored properly.PMID:32569251 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer’s disease. A property common to most cyclin-dependent kinase inhibitors. J Biol Chem. 2001 Jan 5;276(1):251-60.Products are for research use only. Not for human use.|
