Product Name: Cyclin E1 (HE12) Mouse mAb#4129
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation:
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 74115-24-5
Product: Clofentezine
Specificity Sensitivity: Cyclin E1 (HE12) Mouse mAb detects endogenous levels of total cyclin E1 protein. It does not cross react with cyclin E2.
Species Reactivity: Human, Monkey
Source Purification: Monoclonal antibody is produced by immunizing animals with recombinant human cyclin E1.
Background: Cyclin E1 and cyclin E2 can associate with and activate CDK2 (1). Upon DNA damage, upregulation/activation of the CDK inhibitors p21 Waf1/Cip1 and p27 Kip1 prevent cyclin E/CDK2 activation, resulting in G1/S arrest. When conditions are favorable for cell
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20854802?dopt=Abstract
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