Product Name: Phospho-ASK1 (Thr845) Antibody#3765
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation:
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 565460-15-3
Product: URB602
Specificity Sensitivity: Phospho-ASK1 (Thr845) Antibody detects transfected ASK1 only when phosphorylated at threonine 845.
Species Reactivity: Human
Source Purification: Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Thr845 of mouse ASK1. Antibodies are purified by protein A and peptide affinity chromatography.
Background: Apoptosis signal-regulating kinase 1 (ASK1), a MAP kinase kinase kinase, plays essential roles in stress-induced apoptosis (1,2). ASK1 is activated in response to a variety of stress-related stimuli through distinct mechanisms and activates MKK4 and MKK3,
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/23149132?dopt=Abstract
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