Product Name: Presenilin 1 Antibody#3622
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation: 1:100
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 63659-19-8
Product: Betaxolol (hydrochloride)
Specificity Sensitivity: Presenilin 1 Antibody detects endogenous levels of the carboxy-terminal fragment of presenilin 1 (~22 kDa). The antibody detects the full length protein (55k Da) to a lesser extent.
Species Reactivity: Human, Monkey
Source Purification: Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near valine 293 of human presenilin 1. Antibodies are purified by protein A and peptide affinity chromatography.
Background: Presenilin 1 and presenilin 2 are transmembrane proteins belonging to the presenilin family. Mutation of presenilin genes has been linked to early onset of Alzheimer disease, probably due to presenilins associated γ-secretase activity for amyloid-β prote
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/19458037?dopt=Abstract
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