Product Name: Phospho-Tie2 (Tyr992) Antibody#4221
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation:
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 195733-43-8
Product: Atrasentan (hydrochloride)
Specificity Sensitivity: Phospho-Tie2 (Tyr992) Antibody detects transfected levels of Tie2 protein only when phosphorylated at tyrosine 992.
Species Reactivity: Human
Source Purification: Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr992 of human Tie2. Antibodies are purified by protein A and peptide affinity chromatography.
Background: Tie2/Tek is a receptor tyrosine kinase (RTK) expressed almost exclusively on endothelial cells. It is critical for vasculogenesis and could be important for maintaining endothelial cell survival and integrity in adult blood vessels as well as tumor angiog
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/25186262?dopt=Abstract
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