Product Name: Phospho-Syk (Tyr525/526) Antibody#2711
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation:
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 136676-91-0
Product: PD 123319 (ditrifluoroacetate)
Specificity Sensitivity: Phospho-Syk (Tyr525/526) Antibody detects endogenous levels of Syk protein only when phosphorylated at Tyr525/526 of human Syk (Tyr519/520 of mouse Syk). This antibody also cross-reacts with endogenous levels of Zap-70 when phosphorylated at Tyr493.
Species Reactivity: Human
Source Purification: Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr525/526 of human Syk. Antibodies are purified by protein A and peptide affinity chromatography.
Background: Syk is a protein tyrosine kinase that plays an important role in intracellular signal transduction in hematopoietic cells (1-3). Syk interacts with immunoreceptor tyrosine-based activation motifs (ITAMs) located in the cytoplasmic domains of immune recept
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21079812?dopt=Abstract
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