Product Name: Phospho-(Ser/Thr) ATM/ATR Substrate Antibody#2851
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation: 1:20
Immunohistochemistry:
Peptide ELISA: 1:1000
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 77472-70-9
Product: Phenylpiracetam
Specificity Sensitivity: Phospho-(Ser/Thr) ATM/ATR Substrate Antibody detects endogenous levels of proteins containing the ATM/ATR substrate motif. This antibody preferentially binds peptides and proteins that contain phospho-Ser/Thr preceded by Leu or similar hydrophobic amino a
Species Reactivity: Human, Mouse, Rat, Monkey, All Species Expected
Source Purification: Polyclonal antibodies are produced by immunizing animals with synthetic phospho-(Ser/Thr) ATM/ATR substrate peptides . Antibodies are purified by protein A and peptide affinity chromatography.
Background: Ataxia telangiectasia mutated kinase (ATM) and ataxia telangiectasia and Rad3-related kinase (ATR) are related kinases that regulate cell cycle checkpoints and DNA repair (1). The identified substrates for ATM are p53, p95/NBS1, MDM2, Chk2, BRCA1, CtIP, 4
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20451610?dopt=Abstract
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