Product Name: Phospho-SEK1/MKK4 (Ser80) Antibody#9155
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation:
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 195514-80-8
Product: AP20187
Specificity Sensitivity: Phospho-SEK1/MKK4 (Ser80) Antibody detects endogenous levels of SEK1/MKK4 only when phosphorylated at serine 80. This antibody does not cross-react with the corresponding phosphorylated residues of MEK1, MEK2 or MKK3.
Species Reactivity: Human, Mouse, Rat
Source Purification: Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser80 of human SEK1/MKK4. Antibodies are purified by protein A and peptide affinity chromatography.
Background: SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflammatory cytokines (1-3). Activation of SEK1 occurs through MEKK phosphorylation of s
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/23086992?dopt=Abstract
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