Product Name: Phospho-PZR (Tyr241) (D6F9) Rabbit mAb#8131
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation: 1:50
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 22033-87-0
Product: TRO 19622
Specificity Sensitivity: Phospho-PZR (Tyr241) (D6F9) Rabbit mAb recognizes endogenous levels of PZR protein only when phosphorylated at Tyr241.
Species Reactivity: Human, Mouse, Rat, Bovine
Source Purification: Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Tyr241 of human PZR protein.
Background: PZR (Protein zero related) is an immunoglobulin superfamily protein that specifically binds the tyrosine phosphatase SHP-2 through its intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs) (1,2). PZR is phosphorylated by c-Src, c-Fyn, c-Ly
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/23161687?dopt=Abstract
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