Product Name: Phospho-CrkL (Tyr207) Antibody#3181
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation: 1:50
Immunohistochemistry: 1:200
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 200132-83-8
Product: Kasugamycin (hydrochloride hydrate)
Specificity Sensitivity: Phospho-CrkL (Tyr207) Antibody detects endogenous levels of CrkL only when phosphorylated at tyrosine 207. The antibody cross-reacts with CrkII phosphorylated at tyrosine 221.
Species Reactivity: Human, Mouse, Rat, Monkey
Source Purification: Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr207 of human CrkL. Antibodies are purified by protein A and peptide affinity chromatography
Background: CrkL, a 39 kDa adaptor protein, has a key regulatory role in hematopoietic cells. CrkL has one SH2 and two SH3 domains, with 60% homology to CrkII (1). The amino-terminal SH3 domain of CrkL binds proteins such as C3G, SOS, PI3K, c-Abl and BCR/Abl. The SH2
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20668094?dopt=Abstract
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