Product Name: Phospho-β-Arrestin 1 (Ser412) (6-24) Mouse mAb#2416
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation: 1:50
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 61350-00-3
Product: VU0364770
Specificity Sensitivity: Phospho-β-Arrestin 1 (Ser412) (6-24) Mouse mAb detects endogenous levels of β-arrestin 1 only when phosphorylated at serine 412. The antibody does not cross-react with beta-arrestin 2.
Species Reactivity: Human, Mouse, Rat, Monkey
Source Purification: Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser412 of human β-arrestin 1.
Background: Arrestin proteins function as negative regulators of G protein-coupled receptor (GPCR) signaling. Cognate ligand binding stimulates GPCR phosphorylation, which is followed by binding of arrestin to the phosphorylated GPCR and the eventual internalization
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24776644?dopt=Abstract
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