Product Name: CrkL (32H4) Mouse mAb#3182
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation:
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 1173699-31-4
Product: AMG-337
Specificity Sensitivity: CrkL (32H4) Mouse mAb detects endogenous levels of CrkL protein. It does not cross-react with related proteins.
Species Reactivity: Human, Rat, Hamster
Source Purification: Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to amino-terminal residues of human CrkL.
Background: CrkL, a 39 kDa adaptor protein, has a key regulatory role in hematopoietic cells. CrkL has one SH2 and two SH3 domains, with 60% homology to CrkII (1). The amino-terminal SH3 domain of CrkL binds proteins such as C3G, SOS, PI3K, c-Abl and BCR/Abl. The SH2
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/18995831?dopt=Abstract
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