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Antibiotic-resistant gram-negative bacilli (GNB) are increasingly popular causes of healthcare-associated G protein-coupled Bile Acid Receptor 1 Accession infections (HAIs) in intensive care units (ICUs) [1] and are associated with larger mortality prices, longer hospitalizations, and elevated healthcare expenditures [2, 3]. Successful therapy for very drug-resistant (XDR) GNB infections is difficult because of restricted therapeutic solutions [4]. In this study, we examined the epidemiology and outcomes of HAIs attributable to XDR-GNB in the 16 ICUs affiliated with our medical center. We performed a case-control study to determine risk variables associated with XDR-GNB infections compared with non-XDR-GNB infections. We hypothesized that exposure to carbapenem agents could be connected with HAIs brought on by XDR-GNB. Moreover, we performed a survival analysis to explore if predictors for death changed 7, 15, and 30 days right after diagnosis of an HAI. We hypothesized that HAIs brought on by XDR-GNB will be associated with an increased hazard for mortality and that the impact could be most pronounced at 7 days, instead of at 15 or 30 days.Supplies and MethodsStudy Design and style and Study Setting This study was a potential cohort study using a nested, matched case-control study. It was conducted from February 2007 to January 2010 in the 16 ICUs affiliated with NewYorkPresbyterian (NYP) Hospital located in New York City. NYP is really a 2,278-bed (383 ICU-bed) tertiary-care facility affiliated with two medical schools, Columbia University College of Physicians and Surgeons and Weill Cornell Medical College. Study ICUs included healthcare (n=5), surgical (n=6), burn (n=1), and pediatric/neonatal (n=4) ICUs and had approximately 14,800 annual patient admissions. Institutional Review Board approval was obtained fromAm J Infect.