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antioxidantsReviewNrf2 in the Field of Dentistry with Special Attention to NLRPLisa Schieffer 1 , Claudia Manzl 2 , Christoph Schatz 2 , Johannes Haybaeck two,3, and Adriano Crismani 1, Division of Dental and Oral Medicine and Cranio-Maxillofacial and Oral Surgery, Health-related University of Innsbruck, MZA, Anichstr. 35, A-6020 Innsbruck, Austria; [email protected] Institute of Pathology, Neuropathology and Molecular Pathology, Health-related University of Innsbruck, A-6020 Innsbruck, Austria; [email protected] (C.M.); [email protected] (C.S.) Diagnostic H-Ras Formulation Investigation Center for Molecular BioMedicine, Institute of Pathology, Medical University of Graz, A-8036 Graz, Austria Correspondence: [email protected] (J.H.); [email protected] (A.C.)Citation: Schieffer, L.; Manzl, C.; Schatz, C.; Haybaeck, J.; Crismani, A. Nrf2 in the Field of Dentistry with Particular Focus to NLRP3. Antioxidants 2022, 11, 149. doi.org/10.3390/ antiox11010149 Academic Editor: Stanley Omaye Received: 14 December 2021 Accepted: 9 January 2022 Published: 12 January 2022 Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.Abstract: The aim of this critique post was to summarize the functional implications of your nuclear element E2-related issue or nuclear aspect (erythroid-derived two)-like two (Nrf2), with special consideration towards the NACHT (nucleotide-binding oligomerization), LRR (leucine-rich repeat), and PYD (pyrin domain) domains-containing protein 3 (NLRP3) inflammasome within the field of dentistry. NLRP3 plays a vital function in the progression of inflammatory and adaptive immune CYP3 Purity & Documentation responses throughout the body. It can be already known that this inflammasome is actually a important regulator of numerous systemic diseases. The initiation and activation of NLRP3 begins using the oral microbiome and its association together with the pathogenesis and progression of many oral illnesses, such as periodontitis, periapical periodontitis, and oral squamous cell carcinoma (OSCC). The doable function in the inflammasome in oral illness situations may possibly involve the aberrant regulation of a variety of response mechanisms, not just in the mouth but within the complete body. Understanding the cellular and molecular biology in the NLRP3 inflammasome and its relationship to Nrf2 is required for the rationale when suggesting it as a potential therapeutic target for treatment and prevention of oral inflammatory and immunological issues. Within this assessment, we highlighted the present expertise about NLRP3, its most likely role within the pathogenesis of many inflammatory oral processes, and its crosstalk with Nrf2, which might offer future possibilities for disease prevention and targeted therapy in the field of dentistry and oral wellness. Keywords: NLRP3; inflammasome; Nrf2; inflammation; dentistry; oral immunological diseases; or