Name :
FGFR3 (K650E) (Human) Recombinant Protein
Biological Activity :
Human FGFR3 (NP_000133.1, 436 a.a. – 806 a.a.) K650E mutant partial recombinant protein with GST tag expressed in baculovirus infected Sf21 cells.Bioactive Protein,Bioactive Proteins,Bioactive,Active,Functional Protein,Functional Proteins
Tag :
Result of activity analysis
Protein Accession No. :
NP_000133.1
Protein Accession No.URL :
https://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=2261
Amino Acid Sequence :
Molecular Weight :
68
Storage and Stability :
Store at -80°C.Aliquot to avoid repeated freezing and thawing.
Host :
insect
Interspecies Antigen Sequence :
Preparation Method :
Baculovirus infected insect cell (Sf21) expression system
Purification :
Glutathione sepharose chromatography
Quality Control Testing :
Loading 1 ug protein in SDS-PAGE
Storage Buffer :
In 50 mM Tris-HCl, 150 mM NaCl, pH 7.5 (0.1% CHAPS, 1 mM DTT, 10% glycerol)
Applications :
Functional Study， SDS-PAGE，
Gene Name :
FGFR3
Gene Alias :
ACH, CD333, CEK2, HSFGFR3EX, JTK4
Gene Description :
fibroblast growth factor receptor 3
Gene Summary :
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq
Other Designations :
OTTHUMP00000149959|achondroplasia, thanatophoric dwarfism|hydroxyaryl-protein kinase|tyrosine kinase JTK4
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