Product Name: Phospho-p53 (Thr18) Antibody#2529
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation:
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 125494-59-9
Product: Sibutramine (hydrochloride monohydrate)
Specificity Sensitivity: Phospho-p53 (Thr18) Antibody detects endogenous levels of p53 only when phosphorylated at threonine 18.
Species Reactivity: Human
Source Purification: Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Thr18 of human p53. Antibodies are purified by protein A and peptide affinity chromatography.
Background: The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis (1). p53 is phosphorylated at multiple sites in vivo a
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22377765?dopt=Abstract
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