Product Name: Phospho-p130 Cas (Tyr249) Antibody#4014
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation:
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 132866-11-6
Product: Lercanidipine (hydrochloride)
Specificity Sensitivity: Phospho-p130 Cas (Tyr249) Antibody detects endogenous levels of p130 Cas only when phosphorylated at tyrosine 249. The antibody may cross-react with other phosphorylated tyrosines in the substrate domain of p130 Cas.
Species Reactivity: Human, Mouse, Rat
Source Purification: Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr249 of human p130Cas. Antibodies are purified by protein A and peptide affinity chromatography.
Background: p130 Cas (Crk-associated substrate) is a docking protein containing multiple protein-protein interaction domains. The amino-terminal SH3 domain may function as a molecular switch regulating CAS tyrosine phosphorylation, as it interacts with focal adhesion
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/23632970?dopt=Abstract
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