Product Name: Phospho-MLKL (Ser345) Antibody (Mouse Specific)#62233
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation: 1:100
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 1332331-08-4
Product: GSK2194069
Specificity Sensitivity: Phospho-MLKL (Ser345) Antibody (Mouse Specific) recognizes endogenous levels of mouse MLKL protein only when phosphorylated at Ser345. Bands of unknown orgin are detected in some cell lines at around 38 and 150 kDa
Species Reactivity: Mouse
Source Purification: Polyclonal antibodies are produced by immunizing animals with a synthetic phospho-peptide corresponding to residues surrounding Ser345 of mouse MLKL protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background: Necroptosis, a regulated pathway for necrotic cell death, is triggered by a number of inflammatory signals including cytokines in the tumor necrosis factor (TNF) family, pathogen sensors such as toll-like receptors (TLRs), and ischemic injury (1,2). The p
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22547066?dopt=Abstract
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