Product Name: Phospho-β-Catenin (Thr41/Ser45) Antibody#9565
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation:
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 1453097-13-6
Product: HUHS015
Specificity Sensitivity: Phospho-β-Catenin (Thr41/Ser45) Antibody detects endogenous levels of beta-catenin only when phosphorylated at Thr41 or Ser45. This antibody does not recognize β-catenin phosphorylated at other sites.
Species Reactivity: Human, Mouse, Monkey
Source Purification: Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Thr41 and Ser45 of human β-catenin. Antibodies are purified by protein A and peptide affinity chromatography.
Background: β-Catenin is a key downstream effector in the Wnt signaling pathway (1). It is implicated in two major biological processes in vertebrates: early embryonic development (2) and tumorigenesis (3). CK1 phosphorylates β-catenin at Ser45. This phosphorylation
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24009519?dopt=Abstract
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