Product Name: MIB1 Antibody#4400
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation:
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 379270-37-8
Product: GS-7340
Specificity Sensitivity: MIB1 Antibody detects endogenous levels of total MIB1 protein. This antibody does not recognize the Ki-67 (MK167) protein.
Species Reactivity: Human
Source Purification: Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human MIB1 protein. Antibodies were purified by protein A and peptide affinity chromatography.
Background: Mindbomb homolog 1 (MIB1) is an E3 ligase that facilitates the ubiquitination and the subsequent endocytosis of the Notch ligands, Delta and Jagged (1,2). MIB1 appears to promote the ubiquitination and degradation of death-associated protein kinase (DAPK1
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/25135475?dopt=Abstract
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