Product Name: Cleaved PARP (Asp214) (7C9) Mouse mAb (Mouse Specific)#9548
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation:
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 72599-27-0
Product: Miglustat
Specificity Sensitivity: Cleaved PARP (Asp214) (7C9) Mouse mAb (Mouse Specific) detects endogenous levels of the large fragment of mouse PARP1 (89 kDa) resulting from caspase cleavage. The antibody does not recognize full length PARP1 or other PARP isoforms.
Species Reactivity: Mouse
Source Purification: Monoclonal antibody is produced by immunizing animals with a synthetic PARP peptide corresponding to carboxy-terminal residues surrounding Asp214 in mouse PARP.
Background: PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress (1). This protein can be cleaved by many ICE-like caspases in vitro (2,3) and is one of the main cleavage targets of caspase-3 i
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/28413472?dopt=Abstract
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